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| CJC-1293 or modified GRF(1-29) is a synthetic modification of growth hormone releasing factor (GRF) with D-Ala, Gln, Ala, and Leu substitutions at positions 2,8,15,and 27 respectively. These substitutions create a much more stable peptide with the substitution at position 2 to prevent DPP-IV cleavage, at position 8 to reduce asparagine rearrangement or amdie hydrolysis to aspartic acid, position 15 to enhance bio-activity, and position 27 to prevent methionine oxidation. |
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