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| When we workout with weights, the IGF-1 gene is differentially spliced during the body’s response to local muscular overload. First it is spliced to produce predominantly IGF-1Ec (called the MGF splice variant of IGF-1). This initial splicing appears to stimulate satellite cells into activation. This in turn allows the activation of extra undamaged nuclei required for muscle fiber growth and repair to occur. In addition, the appearance of MGF initiates the upregulation of new protein synthesis. After this initial and short lived burst of splicing, IGF-1 production switches towards producing a systemic release of IGF-1Ea from the liver, which upregulates protein synthesis as well, but over a longer time line. This secondary release of IGF-1Ea noticeably less anabolic than the initial release of IGF-1Ec (MGF). |
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